M.Sc
Clinical Biochemistry
Note: The syllabus
prescribed for the entrance test has been divided into fifteen units. Each unit
carries a weightage of four marks. Paper setters are required to set four multiple
choice type questions with only one correct or most appropriate answer separately
for each unit, giving uniform representation to the whole syllabus contained
therein.
Unit
1. General
Science & Computers: Basic concepts of Physics, Chemistry and Computers.
2. Biometrics
and Biostatistics: Statistical
data, ( primary and secondary data), Grouped data( Frequency distribution),
Measures of central tendency, mean, median and mode, Measures of dispersion,
standard deviation, mean deviation, variance, coefficient of variation, Chi-
square distribution.
3. Biochemistry: Structure and
Function of;- Carbohydrates, Lipids, Vitamins, Nucleic acids, Amino acids and
Proteins.
4. Enzymology: History, general
characteristics, nomenclature and classification of enzymes, enzyme activity
and factors affecting enzyme activity, competitive and uncompetitive
inhibition, allosteric enzymes.
5. Cell Biology:
Morphology
of Prokaryotic and Eukaryotic cells. Structure and functions of cell
organelles. Cell Cycle (Mitosis and Meiosis).
6. Metabolism
& nutrition: Syntheisis
(anabolism) and degradation (catabolism) of basic biomolecules;-
Carbohydrates, Lipds, Aminoacids and Nucliec acids. Units of energy, BMR and
its measurement, Protein energy malnutrition.
7. Molecular
Biology: Basic
concepts of genetic information, central dogma of molecular biology, Structural
organization of DNA and RNA. Replication, Transcription and Translation in
prokaryotes and eukaryotes.
8. Microbiology:
Structure,
Classification and Reproduction of viruses and bacteria. Host parasite
relationship. Economic importance of virus and bacteria. Antimicrobial agents
9. Immunology: History, scope
and significance of immunology, Basic concepts of specific and Non-specific
immune responses. Structure and function of Immunolglobulins.
10. Genetics: Mendelian
Genetics; laws and principles of segregation, independent assortment. Linkage
and Crossing over. Chromosome organization; Structural and Numerical changes in
chromosomes.
11.
Biotechnology: Concept
and basic principles of recombinant DNA technology (RDT). Applications of
genetic engineering in medical and agricultural sciences.
12. Clinical
Biochemistry: Basic
concepts and principles of Clinical Biochemistry. Standard values for important
constituents in blood and urine. Kidney, Liver and thyroid function tests (KFT,
LFT,TFT). Lipid profile. Glucose tolerance tests. Urine and stool examination.
13. Human
Physiology:-
Components and functions of Blood
and lymph. General organization and physiological functions of Respiratory,
Excretory, Digestive, Endocrine and Nervous system.
14. Plant
Physiology –
Photostnthesis, Respiration, Transpiration in Plants. Plant growth hormones.
Transport across the plant cells.
15. Chemistry
concepts:
Basic organic reaction mechanisms;
Oxidation-reduction, Redox potential, coupled reactions, Elimination,
Isomerization and rearrangements. Dipole-dipole interactions, Hydrogen bonds,
vanderwaals forces Concepts of acids and bases. Electrophiles and nucleophiles.
Chemical kinetics and catalysis; orders of reactions, concepts of activation
energy and reaction rates, laws of photochemistry, photochemical reactions.
Laws of thermodynamics.
